Value of a single serum CA-125 in the prediction of miscarriage in women presenting with first trimester abortion

CA-125 levels are raised during all processes involving decidual activity [early pregnancy, immediately after birth and bleeding episodes during pregnancy]. In this study we investigated the usefulness of determining maternal single serum levels of CA-125 in maternal serum as a predictor of the fate of the bleeding episode in women presenting with first trimester abortion. The study is a prospective controlled study. Inclusion criteria including vaginal spotting, transvaginal ultrasound evidence of living intrauterine embryo or fetus, monovular pregnancy, normal ovaries seen by ultrasound and gestational age between 6-12 weeks. Exclusion criteria are multiple pregnancy, ovarian masses and pelvic endometriosis. Our study included 95 pregnant patients in their first trimester of pregnancy [40 patients [42.2%] in the abortion group who actually terminated their conceptions, 30 patients [31.5%] in the recovery group who successfully overcame the bleeding episode and continued their pregnancy, and 25 patients [26.3%] as a control group, who have no bleeding]. Our results showed that the abortion group tends to have a significantly lower duration of conception than the other two groups. As regards CA-125 levels, the p value was 0.00 for recovery vs. abortion groups [highly significant], 0.0006 [highly significant] for recovery vs. control groups, and 0.00 for abortion vs. control groups [highly significant]. The test yielded a sensitivity of 93.33% and a specificity of 95.38%. Such results lead to the conclusion that determination of CA-125 level in maternal serum during a bleeding episode in the first trimester of pregnancy has a significant predictive ability as regards the outcome of pregnancy

Congential t-cell immunodeficiency with post BCG systemic TB infection

Objectives and important to report a case of congenital T-ceIl immunodeficiency with post BCG vaccination systemic TB infection. clinical presentation 6 months old infant presented by respiratory symptoms, light coma, FTT and HSM. Initial investigation CXR showed miliary opacities in both lungs, abdominal U/S showed hepatosplenomegally [HSM] with homogenous echogenicity. CT brain W out contrast showed ventricular dilatation and encephalomalacia and brain distortion, immunological study showed total immunoglobins and IgG, IgM, IgA, IgD, IgE were within normal range. T-lymphocytes showed decrease in total lymphocytes and decease in T4 [T-helper] T8 [T-suppressor] NK [Natural killer] suggests T-cell immunodeficiency. CBC showed microcytic hypochromic anemia[HB 8.5gm/dl] anemia of chronic illness, Screening for IIIV infection negative

Study of thrombomodulin level in infants with respiratory problems of diabetic mothers

In our study, we found statistical significant increase in the soluble form of thrombomodulin PTM was positively correlated to the duration of the disease, age of the mother, PCO2 [in BOA] and CRP. The longer the duration of symptoms, the older the age of the mother or the higher in the PCO2 or CRP +ve, the higher will be PTM. In the other hand, PTM was negatively correlated to gestational age, Apgar score, PH in [BOA], HCO3 in [BGA] and platelet count. The in the Apgar score, PH, HCO3 and platelet count, the lower will be PTM level